ประชาสัมพันธ์โครงการ “จากนวัตกรรมสู่การทำธุรกิจด้านผลิตภัณฑ์สุขภาพ 2566”
07/02/2023สอวช. เยี่ยมชมโรงงานและศูนย์ผลิตบริการคณะการแพทย์บูรณาการ
07/02/2023
ประชุมคณะกรรมการขับเคลื่อนการบริหารงานเพื่อความเป็นเลิศ 3/2565
11/05/2022ประชาสัมพันธ์ โครงการการสกัดน้ำมันกัญชา
12/05/2022
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Myofascial Pain Syndrome Focused on the Upper Trapezius Muscle: A Comparative Randomized Controlled Trial of the Court-Type Traditional Thai Massage versus the Thai Hermit
27/03/2022
โครงการ จากนวัตกรรมสู่การทำธุรกิจด้านผลิตภัณฑ์สุขภาพ กิจกรรมที่ 2 การประกวดและนำเสนอแผนการทำธุรกิจด้านผลิตภัณฑ์สุขภาพ
28/03/2022Evaluation of anti-inflammatory effect of Moringa oleifera lam. And Cyanthillium cinereum (less) h. rob. lozenges in volunteer smokers
List of authors
1 Cellular and Molecular Immunology Research Unit, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok 65000, Thailand
2 Thai Traditional Medicine College, Rajamangala University of Technology Thanyaburi, Pathum Thani 12130, Thailand
3 Wang Thong Hospital, Phitsanulok 65130, Thailand
4 Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Naresuan University, Phitsanulok 65000, Thailand
5 Faculty of Dentistry, Naresuan University, Phitsanulok 65000, Thailand
Abstract
Smokers have high plaque accumulation that initiates gingival inflammation and progresses to periodontitis. Thus, oral hygiene to control microbial plaque formation is an effective method of preventing gingivitis. Medicinal plants such as Moringa oleifera Lam. (MO) and Cyanthillium cinereum (Less.) H. Rob. (CC) have an anti-inflammatory effect that might improve oral health in smokers. This study evaluated the effect of MO leaf and CC extracts using MO lozenges and a combination of MO + CC lozenges on oral inflammation and gingivitis in volunteer smokers. Lozenges consisting of MO and CC extracts were developed and studied in vivo. The results showed that lozenges significantly reduced oral inflammation and gingivitis in volunteers. The gingival index (GI) of group III (MO + CC lozenges) significantly decreased, while the percentage decrease of oral inflammation in group II (MO lozenges) was significantly higher than the other groups. The percentage decrease of GI values in group II (MO lozenges) and group III (MO + CC lozenges) were significantly higher than the placebo group I. Our findings indicated that MO and MO + CC lozenges reduced oral inflammation and gingivitis and showed potential to improve oral health in smokers. View Full-Text
* Author to whom correspondence should be addressed.
Academic Editor: Monika Czerwinska
Plants 2021, 10(7), 1336; https://doi.org/10.3390/plants10071336
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Anti-aging potential and phytochemicals of Centella asiatica, Nelumbo nucifera, and Hibiscus sabdariffa extracts
27/03/2022Evaluation of anti-inflammatory effect of moringa oleifera lam. And cyanthillium cinereum (less) h. rob. lozenges in volunteer smokers
27/03/2022Myofascial Pain Syndrome Focused on the Upper Trapezius Muscle: A Comparative Randomized Controlled Trial of the Court-Type Traditional Thai Massage versus the Thai Hermit
List of authors
Abstract
Myofascial pain syndrome is a common problem that can develop at any age. This study compares the efficacy of the court-type traditional Thai massage (CTTM) to the Thai hermit exercise (THE) in improving the cervical range of motion (CROM) and reducing pain in the upper trapezius muscle. In this study, 46 patient subjects were randomized into 2 groups, with 1 group administered CTTM and the other administered THE. Prior to and following the experiment, their demographic characteristics, pain levels and CROM were measured using a visual analog scale (VAS) and a goniometer, respectively. Data was then analyzed using descriptive statistics, percentage, mean, and standard deviation, as well as inferential statistics. The findings indicate that subjects in both groups demonstrated significantly lower pain and significantly better CROM (P < 0.05). In terms of comparative treatment between the CTTM and THE groups, the results were not found to differ in the range of motion, but a clear difference in pain level measured by VAS was found, in which CTTM provides a better way of reducing pain at the trigger point than THE (P < 0.05). From the findings, it can be concluded that both CTTM and THE are comparably efficacious therapies for myofascial pain in the upper trapezius muscle. View Full-text
Keywords: massage therapy; pain management; traditional medicine.
* Author to whom correspondence should be addressed.
Boonruab J, Poonsuk P, Damjuti W, Supamethangkura W. Myofascial Pain Syndrome Focused on the Upper Trapezius Muscle: A Comparative Randomized Controlled Trial of the Court-Type Traditional Thai Massage versus the Thai Hermit. J Evid Based Integr Med. 2021 Jan-Dec;26:2515690X211030852. doi: 10.1177/2515690X211030852. PMID: 34293959; PMCID: PMC8312165.
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Chemical evaluation and antibacterial activity of novel bioactive compounds from endophytic fungi in Nelumbo nucifera
27/03/2022Myofascial Pain Syndrome Focused on the Upper Trapezius Muscle: A Comparative Randomized Controlled Trial of the Court-Type Traditional Thai Massage versus the Thai Hermit
27/03/2022Anti-aging potential and phytochemicals of Centella asiatica, Nelumbo nucifera, and Hibiscus sabdariffa extracts
List of authors
1Department of Innovation of Health Products, Thai Traditional Medicine College, Rajamangala University of Technology Thanyaburi, Pathum Thani, Thailand
2Department of Applied Thai Traditional Medicine, Thai Traditional Medicine College, Rajamangala University of Technology Thanyaburi, Pathum Thani, Thailand
Abstract
Centella asiatica, Nelumbo nucifera Gaertn, and Hibiscus sabdariffa have been used as medicinal plants in Thailand. They are sources of phytochemicals that applications for esthetic and healthcare. The aim of this research was to examine the phytochemical constituents and anti-aging potential of these plants. The phytochemical compounds were performed using gas chromatography-mass spectrometry. The anti-aging activities were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azinobis (3-ethylbenzothiazoline-6-sunfonic acid) (ABTS), anti-collagenase, and anti-elastase assays. The main interest phytochemical compounds of ethanolic extracts of C. asiatica, N. nucifera, H. sabdariffa were ethanol, 2-(-Octadecenyloxy), γ-sitosterol and hexadecanoic acid, and ethyl ester, respectively. The DPPH half-maximal inhibitory concentration (IC50) results of C. asiatica, N. nucifera, and H. sabdariffa were 0.32 ± 0.01, 0.34 ± 0.00, and 0.35 ± 0.01 mg/mL, respectively. The ABTS result of H. sabdariffa extract showed high inhibitory activity at IC50 of the extract was 0.62 ± 0.12 mg/mL. The percentage of collagenase inhibition of C. asiatica, N. nucifera, and H. sabdariffa at 1.0 mg/mL was 78.13 ± 4.42, 85.94 ± 2.21, and 90.63 ± 0.00, respectively. The C. asiatica extract had a high percentage of elastase inhibition. Consequently, these research results suggest that phytochemicals may also provide a range of esthetic and health benefits. The phytochemical constituent could be used as anti-aging active ingredient for cosmetic and pharmaceutical industrials. View Full-Text
Key words: Anti-aging, Centella asiatica, Hibiscus sabdariffa, Nelumbo nucifera, phytochemical
* Author to whom correspondence should be addressed.
Khuanekkaphan, M., Noysang, C., & Khobjai, W. (2020). Anti-aging potential and phytochemicals of Centella asiatica, Nelumbo nucifera, and Hibiscus sabdariffa extracts. Journal of advanced pharmaceutical technology & research, 11(4), 174–178. https://doi.org/10.4103/japtr.JAPTR_79_20
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Optimization of water-based ultrasonicmicrowave-assisted extraction (UMAE) of bioactive compounds from Garcinia mangostana pericarp
27/03/2022Anti-aging potential and phytochemicals of Centella asiatica, Nelumbo nucifera, and Hibiscus sabdariffa extracts
27/03/2022Chemical evaluation and antibacterial activity of novel bioactive compounds from endophytic fungi in Nelumbo nucifera
List of authors
SurachaiTechaoeiabChariyaJirayuthcharoenkulaKhemjiraJarmkomabThisakornDumrongphuttidechaabWarachateKhobjaic
- a Thai Traditional Medicine College, Rajamangala University of Technology Thanyaburi 12130 Thailand
- b Innovation of Plants Extraction and Biological Activity for Pharmaceutical Products, Food Supplement and Medical Drugs, Thai Traditional Medicine College, Rajamangala University of Technology Thanyaburi 12130 Thailand
- c Department of Clinical Chemistry, Faculty of Medical Technology, Nation University No. 444 Vajiravuth Damnern Road, Prabat Sub-district, Mueang District, Lampang 52000, Thailand
Abstract
The objective of this study was to characterize an endophytic fungi producing-bioactive compound from the aquatic plant, Nelumbo nucifera. All parts of such plant were cleaned with surface sterilization technique and cultured on potato dextrose agar to isolate endophytic fungi. The identification was characterized by morphological and molecular technique. Fungal isolates were screened to discover antimicrobial activities by disc diffusion method against Methicillin-resistant Staphylococcus aureus DMST20651 (MRSA). MIC and MBC for those crude fungal extracts were determined. Finally, the chemical profile of crude extract was determined by gas chromatography and mass spectrometry. Six endophytic fungi were isolated from the surface-satirized parts of N. nucifera. Based on disc diffusion assay, the highest antibacterial activity against MRSA was isolate ST9.1 identified as Aspergillus cejpii. Results demonstrated that the ethyl acetate extraction had more active fractions with MIC of 2.5 mg/ml and MBC concentration of 50.0 mg/ml. The crude extracts were developed to identify the chemical constituents by gas chromatography and mass spectrometry. The major component of crude extract of endophytic fungi was 5-(1H-Indol-3-yl)-4,5-dihydro-[1,2,4]triazin-3-ylamine (C11H11N5). Thus, the plant could be used in the treatment of infectious diseases caused by bacterial pathogen. View Full-text
* Author to whom correspondence should be addressed.
Techaoei, S., Jirayuthcharoenkul, C., Jarmkom, K., Dumrongphuttidecha, T., & Khobjai, W. (2020). Chemical evaluation and antibacterial activity of novel bioactive compounds from endophytic fungi in Nelumbo nucifera. Saudi Journal of Biological Sciences, 27(11), 2883–2889. https://doi.org/10.1016/j.sjbs.2020.08.037
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Development of ability to perform activities of daily living of bedridden elderly people by Thai traditional medicine
27/03/2022Chemical evaluation and antibacterial activity of novel bioactive compounds from endophytic fungi in Nelumbo nucifera
27/03/2022Optimization of water-based ultrasonicmicrowave assisted extraction (UMAE) of bioactive compounds from Garcinia mangostana pericarp
Abstract
Objectives: Garcinia mangostana (GM) pericarp extract recognizes for relieving skin disorders. It becomes a household fruit juice due to its high concentration of antioxidant compounds, including phenolic and α-mangostin. The purpose of this study was to optimize the conditions of Ultrasonic-Microwave Assisted Extraction (UMAE) of GM pericarp.
Methods: GM pericarp was extracted by UMAE and conventional decoction extraction. UMAE was created in nine different individuals and combined ultrasonic and microwave power. The amount of phenolic compound, "caffeic acid, ferulic acid", α-mangostin, and total phenolic content (TPC) were compared. The optimized parameters were particle size of grounded raw material, microwave power, and ultrasonic power during water extraction.
Results: The optimized UMAE conditions combined 200 W microwave power and 200 W ultrasonic power to extract raw material grounded to 22.6 μm diameter particles (p≤0.05). The synergistic effect of ultrasonic and microwave-assisted extraction significantly (p≤0.05) impacted on the TPC, the yield of caffeic acid, ferulic acid, and α-mangostin.
Conclusions: Overall, the synergistic effect of ultrasonic and microwave extraction resulted in a significantly higher amount of bioactive compounds when compared to conventional decoction extraction (p≤0.001). These results demonstrated the advantages of UMAE for preparing GM pericarp extract for the food, cosmetic and pharmaceutical industries.
Keywords: Garcinia mangostana; green extraction; microwave assisted extraction (MAE); phenolic; ultrasonic assisted extraction (UAE); α-mangostin.
* Author to whom correspondence should be addressed.
Kwansang J, Chen CJ, Chaiprateep EO. Optimization of water-based ultrasonic-microwave assisted extraction (UMAE) of bioactive compounds from Garcinia mangostana pericarp. J Complement Integr Med. 2022 Jan 17. doi: 10.1515/jcim-2021-0454. Epub ahead of print. PMID: 35038813.
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Development Gel Product Containing Herbal Compress Extract withAntioxidant Activity
27/03/2022Optimization of water-based ultrasonicmicrowave-assisted extraction (UMAE) of bioactive compounds from Garcinia mangostana pericarp
27/03/2022Development of ability to perform activities of daily living of bedridden elderly people by Thai traditional medicine
List of authors
Laddawan Choothong1*Yamila Domea2
1 Faculty of Integrative Medicine, Rajamangala University of Technology Thanyaburi, Pathum Thani 12130, Thailand
2 Faculty of Integrative Medicine, Rajamangala University of Technology Thanyaburi, Pathum Thani 12130, Thailand
Abstract
The purpose of this study was to assess the ability to perform basic Activities of Daily Living (ADL)of bedridden elderly before and after being developed by using Thai traditional medicine(massage and herbalcompress).In this studyPDCA was appliedasaresearch method. The target group was specifically selected including30 bedridden elderly people in Bang Phun, Mueang Pathum Thani Provincewith the ADLscore of lessthan 12. The tool used in this study included,the Barthel ADL index was used.The statistics used for data analysis included frequency, percentages, means, and standard deviation.The findings of this study clearly showedthelevels of ability to perform activities of dailylivingbefore andafter the application of Thai traditional medicine.The level of ability of moderate dependency was reduced from 70.00%to56.67%while thethat of theelderly people with stightly less dependency in thegroup was reduced from 6.67%to 20.00%. Thecomparison of mean score differencesof the ability to perform ADLof the bedridden elderlybefore and after the application of Thai traditional medicine showed that the life quality score increased from 7.53 to7.87afterthe application of Thai traditionalmedicine. Therefore, the ability to perform basic daily activities of bedridden elderly was increasing and a significant and statistical proven difference (P < 0.05) have been observed. View Full-text
Keywords:Capacity in activitiesof daily living, Bedridden elderly, Thai traditional medicine
* Author to whom correspondence should be addressed.
